Pygmy populations seronegative for Marburg virus

Excerpt from CDC website: "...A serosurvey was conducted in Durba, a mining village near Watsa, northeastern Democratic Republic of Congo, the epicenter of Marburg hemorrhagic fever (MHF) outbreaks in 1994 and 1998–2000 (1–3). In this survey, Bausch et al. found a prevalence of anti-Marburg immunoglobulin (Ig) G of 0.35% (2 of 565) in the nonmining population, but a prevalence of 3.75% (13 of 347) in miners. Mine work was an independent risk factor for seropositivity for anti-Marburg IgG (1). Given that widespread secondary transmission could not be documented in the seropositive miners, primary transmission from the unknown reservoir likely occurred in the mines where rodent, shrew, bat, and other fauna were abundant. No evidence of Marburg virus (MBGV) infection was found in samples from small mammals, amphibians, and arthropods collected in and around Gorumbwa mine (R. Swanepoel, pers. comm.); the origin of the MHF outbreak remained unknown...We hypothesized that the MBGV reservoir's habitat might not be limited to gold mines around Durba, but may exist in caves or forests in the wider Watsa area. As hunter-gatherers, pygmies enter caves for shelter and are in frequent contact with wild animals and body fluids of butchered game. Earlier studies found that pygmies were seropositive for filoviruses significantly more often than subsistence farmers (for filoviruses [4,5], for Ebola but not Marburg [6]). We conducted a seroprevalence study to verify whether pygmies living in the Watsa area constitute another population at risk for primary transmission of MBGV..."

Comments: Enregistrer un commentaire

<< Home

This page is powered by Blogger. Isn't yours?